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Nat Rev Cancer. 2003 Oct;3(10):756-67.

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

Author information

  • 1Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland. Freddy.Radtke@isrec.unil.ch

Abstract

Notch signalling participates in the development of multicellular organisms by maintaining the self-renewal potential of some tissues and inducing the differentiation of others. Involvement of Notch in cancer was first highlighted in human T-cell leukaemia, fuelling the notion that aberrant Notch signalling promotes tumorigenesis. However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor.

PMID:
14570040
[PubMed - indexed for MEDLINE]
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