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Cell. 2003 Oct 17;115(2):132-3.

R2D2 leads the silencing trigger to mRNA's death star.

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  • 1Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.

Abstract

During RNA interference (RNAi), Dicer generates short interfering RNAs (siRNAs), which then guide target mRNA cleavage by the RISC complex. Now, Liu et al. identify R2D2, a Dicer-associated protein that is important for siRNA incorporation into RISC, thus linking the initiation and execution phases of RNAi.

PMID:
14567910
[PubMed - indexed for MEDLINE]
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