TSH, the bone suppressing hormone

Cell. 2003 Oct 17;115(2):129-30. doi: 10.1016/s0092-8674(03)00812-2.

Abstract

The skeleton is a dynamic organ whose structural integrity depends on constant remodeling, controlled by many local and systemic factors. In this issue of Cell, identify thyroid-stimulating hormone (TSH) as an important regulator of this process.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bone Density / drug effects
  • Bone Remodeling / drug effects*
  • Bone and Bones / physiology
  • Cell Differentiation
  • Cells, Cultured
  • Glycoproteins / metabolism
  • Mice
  • Mice, Knockout
  • Osteoprotegerin
  • Receptors, Cytoplasmic and Nuclear / metabolism
  • Receptors, Thyrotropin / metabolism
  • Receptors, Tumor Necrosis Factor
  • Thyrotropin / metabolism
  • Thyrotropin / physiology*

Substances

  • Glycoproteins
  • Osteoprotegerin
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Thyrotropin
  • Receptors, Tumor Necrosis Factor
  • Tnfrsf11b protein, mouse
  • Thyrotropin