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Nat Neurosci. 2003 Nov;6(11):1141-2. Epub 2003 Oct 19.

A functional genetic variation of the 5-HT2a receptor affects human memory.

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  • 1Division of Psychiatry Research, University of Zürich, Lenggstr. 31, 8029 Zürich, Switzerland.


Human memory capacity is highly variable across individuals and is influenced by both genetic and environmental factors. A roughly 50% heritability estimate indicates that naturally occurring genetic variations have an important impact on this cognitive ability. Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant.

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