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Science. 2003 Oct 17;302(5644):406-7.

Medicine. PPARs as therapeutic targets: reverse cardiology?

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  • 1Department of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. jplutzky@rics.bwh.harvard.edu

Abstract

Formation of the atherosclerotic lesions that lead to myocardial infarction is determined in part by inflammatory responses such as the production of lipid-laden macrophages. In his Perspective, Plutzky highlights the parts played by PPAR nuclear receptors, especially PPAR-delta (Lee et al.), in the modulation of inflammatory responses and hence atherosclerosis.

PMID:
14563997
[PubMed - indexed for MEDLINE]
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