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Dig Liver Dis. 2003 Sep;35(9):612-8.

Breath test is very reliable for diagnosis of Helicobacter pylori infection in real clinical practice.

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  • 1Service of Gastroenterology, Hospital Universitario Miguel Servet, Zaragoza, Spain. fgomollon@able.es

Abstract

AIMS:

To determine the accuracy of the most common available tests for the diagnosis of Helicobacter pylori infection in an unselected and untreated population of patients.

PATIENTS AND METHODS:

Prospective study including 314 unselected patients from a population of 814 patients referred for upper endoscopy at one hospital. H. pylori infection was diagnosed by rapid urease test (RUT), histology, culture and 13C-urea-breath test (UBT) and serum IgG (EIA). H. pylori infection was defined as positive if culture or at least two of the other tests were positive.

RESULTS:

The prevalence of H. pylori infection in this population was 72%. The diagnostic test with the greatest combination of sensitivity (97%) and specificity (100%) was the UBT. EIA had a good sensitivity (96%), but it was the test with the least specificity (71%). RUT, histology and culture showed a high specificity (>98%) but a sensitivity lower than 90%. In elderly patients (>65 years old, n=120), UBT was also the test with the greatest combination of sensitivity (94%) and specificity (100%).

CONCLUSIONS:

In conditions of real clinical practice the 13C-urea-breath test is a reliable test for H. pylori diagnosis, both in young and elderly patients.

PMID:
14563182
[PubMed - indexed for MEDLINE]
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