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Semin Immunol. 2003 Jun;15(3):167-76.

Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology.

Author information

  • 1Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstrasse 31, P.O. Box 62, 3010 Bern, Switzerland. tbrunner@pathology.unibe.ch

Abstract

Members of the tumor necrosis factor (TNF) superfamily are crucially involved in the regulation of T cell activation, homeostasis and cytotoxicity. In particular, Fas ligand (FasL), expressed by activated T lymphocytes, induces cell-mediated cytotoxicity and may also be responsible for apoptotic suicide. Tight regulation of this death-inducing ligand is a prerequisite for proper immune defense and homeostasis. In this review, we will discuss various aspects of FasL regulation in cell-mediated cytotoxicity, immune homeostasis and the immunopathology of diseases.

PMID:
14563115
[PubMed - indexed for MEDLINE]
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