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Curr Biol. 2003 Oct 14;13(20):R799-801.

Mg2+ homeostasis: the Mg2+nificent TRPM chanzymes.

Author information

  • Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. cmontell@jhmi.edu


TRPM6 and TRPM7 are distinct from all other ion channels in that they are composed of linked channel and protein kinase domains. Recent studies demonstrate that these 'chanzymes' are essential for Mg(2+) homeostasis, which is critical for human health and cell viability.

[PubMed - indexed for MEDLINE]
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