Rinsho Byori. 2003 Sep;51(9):892-7.

[Urate transporter and renal hypouricemia].

[Article in Japanese]

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Nagoya University Hospital, Department of Clinical Preventive Medicine, Nagoya 466-8560.

Abstract

Urate, a purine metabolite, is a cause of gout(hyperuricemia), which is an independent risk factor for cardiovascular disease. Urate is a scavenger of reactive oxygen radicals that are involved in numerous diseases. Because humans have a renal urate reabsorption system and have lost hepatic uricase by mutational silencing in evolution, urate is present in human blood at high levels. We identified the long-hypothesized urate transporter in the human kidney (URAT1, encoded by SLC22A12), a urate anion exchanger regulating blood urate levels and targeted it with uricosuric and antiuricosuric agents. Moreover, we demonstrated that patients with renal hypouricemia have mutational defects in SLC22A12.

PMID:: 14560659; [PubMed - indexed for MEDLINE]

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Cited by 1 PubMed Central article

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