Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Biochem Sci. 1992 Nov;17(11):474-8.

Signal peptidases in prokaryotes and eukaryotes--a new protease family.

Author information

  • 1Department of Chemistry, Ohio State University, Columbus 43210.

Erratum in

  • Trends Biochem Sci 1993 Jan;18(1):25.

Abstract

Signal peptidases remove targeting peptides from pre-proteins and play central roles in the secretory pathway, as well as in the delivery of proteins to the mitochondrial intermembrane space and to the lumen of thylakoids. The catalytic mechanism of pre-protein cleavage has long been an enigma, but recent data from site-directed mutagenesis and sequence alignment studies suggest that signal peptidases may constitute a new type of serine protease, mechanistically related to the beta-lactamases.

PMID:
1455520
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk