Abstract
This review discusses the pharmacology of antidepressants as it relates to their blockade of human transporters for norepinephrine, serotonin, and dopamine, as well as their blockade of several different human neurotransmitter receptors. This blockade by antidepressants of transporters and receptors is thought to relate to therapeutic and adverse effects of these compounds. Knowledge of the preclinical pharmacology of antidepressants will help the clinician to identify adverse effects and drug interactions that may occur with these agents. The article also reviews drugs that have dual action (effects on serotonin and norepinephrine), which may provide a therapeutic advantage in treating depressed patients.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antidepressive Agents / pharmacology*
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Antidepressive Agents / therapeutic use*
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Carrier Proteins / antagonists & inhibitors
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Carrier Proteins / drug effects
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Carrier Proteins / physiology
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Depressive Disorder / drug therapy*
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Depressive Disorder / physiopathology
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Drug Interactions
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Humans
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Membrane Glycoproteins / antagonists & inhibitors
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Membrane Glycoproteins / drug effects
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Membrane Glycoproteins / physiology
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Membrane Transport Proteins / drug effects
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Membrane Transport Proteins / physiology*
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Nerve Tissue Proteins*
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Neurotransmitter Agents / physiology*
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Norepinephrine Plasma Membrane Transport Proteins
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Receptors, Neurotransmitter / antagonists & inhibitors
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Receptors, Neurotransmitter / drug effects
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Receptors, Neurotransmitter / physiology
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Serotonin Plasma Membrane Transport Proteins
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Symporters / antagonists & inhibitors
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Symporters / physiology
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Synapses / drug effects
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Synapses / physiology
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
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Treatment Outcome
Substances
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Antidepressive Agents
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Carrier Proteins
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Membrane Glycoproteins
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Membrane Transport Proteins
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Nerve Tissue Proteins
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Neurotransmitter Agents
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Norepinephrine Plasma Membrane Transport Proteins
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Receptors, Neurotransmitter
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SLC6A2 protein, human
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SLC6A4 protein, human
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Serotonin Plasma Membrane Transport Proteins
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Symporters