Histiocytic lesions involving the bone marrow

Semin Diagn Pathol. 2003 Aug;20(3):226-36. doi: 10.1016/s0740-2570(03)00030-3.

Abstract

Histiocytic lesions involving the bone marrow include a number of reactive and neoplastic disorders. This article discusses the morphologic, immunophenotypic, and genotypic features of a variety of diseases associated with histiocytes and/or monocytes. Lysosomal storage disorders and hemophagocytic syndromes are often first diagnosed by bone marrow examination. Granulomas involving the bone marrow may also be the first indication of a systemic disorder. Apart from acute and chronic monocytic leukemias, the bone marrow is rarely involved by malignant histiocytic disorders, of which Langerhans cell histiocytosis is the most common.

Publication types

  • Review

MeSH terms

  • Bone Marrow / pathology*
  • Genotype
  • Histiocytes / pathology*
  • Histiocytosis / genetics
  • Histiocytosis / immunology
  • Histiocytosis / pathology*
  • Humans
  • Immunophenotyping