Science. 2003 Oct 10;302(5643):237-9.

Neuroscience. Feeling the pain of social loss.

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J. P. Scott Center for Neuroscience, Mind and Behavior, Department of Psychology, Bowling Green State University, Bowling Green, OH 43403, USA. jpankse@bgnet.bgsu.edu

Abstract

Poets have long waxed lyrical about the pain of a broken heart. Now, as Panksepp explains in his Perspective, this metaphor may reflect real events in the mammalian brain. A new brain neuroimaging study (Eisenberger et al.) reveals that the brain areas that are activated during the distress caused by social exclusion are also those activated during physical pain. Thus, we now have an explanation for the feeling of physical pain that accompanies emotional loss-whether that be the loss of a loved one, rejection by one's social group, or the distress of separation experienced by young animals.

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Science. 2003 Oct 10;302(5643):290-2.

PMID:: 14551424; [PubMed - indexed for MEDLINE]

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Does rejection hurt? An FMRI study of social exclusion. [Science. 2003]
Does rejection hurt? An FMRI study of social exclusion.
Eisenberger NI, Lieberman MD, Williams KD. Science. 2003 Oct 10; 302(5643):290-2.
[Emotional and physical pain are processed by the brain in a similar way]. [Lakartidningen. 2004]
[Emotional and physical pain are processed by the brain in a similar way].
Kahl U. Lakartidningen. 2004 Feb 12; 101(7):564-5.
Review The neural bases of social pain: evidence for shared representations with physical pain. [Psychosom Med. 2012]
Review The neural bases of social pain: evidence for shared representations with physical pain.
Eisenberger NI. Psychosom Med. 2012 Feb-Mar; 74(2):126-35. Epub 2012 Jan 27.
Can we share a pain we never felt? Neural correlates of empathy in patients with congenital insensitivity to pain. [Neuron. 2009]
Can we share a pain we never felt? Neural correlates of empathy in patients with congenital insensitivity to pain.
Danziger N, Faillenot I, Peyron R. Neuron. 2009 Jan 29; 61(2):203-12.
Review Why rejection hurts: a common neural alarm system for physical and social pain. [Trends Cogn Sci. 2004]
Review Why rejection hurts: a common neural alarm system for physical and social pain.
Eisenberger NI, Lieberman MD. Trends Cogn Sci. 2004 Jul; 8(7):294-300.

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Cited by 12 PubMed Central articles

Language development after cochlear implantation: an epigenetic model. [J Neurodev Disord. 2011]
Language development after cochlear implantation: an epigenetic model.
Markman TM, Quittner AL, Eisenberg LS, Tobey EA, Thal D, Niparko JK, Wang NY, The CDaCI Investigative Team. J Neurodev Disord. 2011 Dec; 3(4):388-404. Epub 2011 Nov 19.
Social rejection shares somatosensory representations with physical pain. [Proc Natl Acad Sci U S A. 2011]
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Kross E, Berman MG, Mischel W, Smith EE, Wager TD. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6270-5. Epub 2011 Mar 28.
Affective neuroscience of the emotional BrainMind: evolutionary perspectives and implications for understanding depression. [Dialogues Clin Neurosci. 2010]
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