Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Neurosci Lett. 2003 Nov 6;351(1):25-8.

Histamine elicits neuronal excitatory response of red nucleus in the rat via H2 receptors in vitro.

Author information

  • 1Department of Biological Science and Technology, Nanjing University, 22 Hankou Road, Nanjing 210093, China.


Perfusing slices with histamine (1-100 microM) produced an excitatory response in rat rubral neurons (118/132, 89.4%). The histamine-induced excitation was not blocked by the low-Ca2+/high-Mg2+ medium (n=10), supporting a direct postsynaptic action of the amine. Histamine H2 receptor antagonist ranitidine effectively blocked the excitatory response of rubral neurons to histamine (n=26), but H1 receptor antagonist triprolidine did not (n=24). The excitatory effect of histamine could be mimicked by dimaprit, a highly selective H2 receptor agonist (n=24), and the dimaprit-elicited excitation of the rubral neurons could be blocked by ranitidine (n=16), but not by triprolidine (n=9). In addition, H1 receptor agonist 2-pyridylethylamine could not elicit any response in rubral neurons (n=12). These results indicate that histamine excites red nucleus neurons through H2 receptors and suggest that the histaminergic afferent fibers may play an important functional role in the sensorimotor integration through the red nucleus.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk