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Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11486-9.

Borna disease virus, a negative-strand RNA virus, transcribes in the nucleus of infected cells.

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  • 1Institute of Virology, Free University of Berlin, Federal Republic of Germany.


Borna disease virus, an unclassified infectious agent, causes immune-mediated neurologic disease in a wide variety of animal hosts and may be involved in pathogenesis of selected neuropsychiatric diseases in man. Initial reports suggested that Borna disease virus is a single-stranded RNA virus. We describe here a method for isolation of viral particles that has allowed definitive identification of the genome as containing a negative-polarity RNA. Further, we show that the viral mRNAs are transcribed in the nucleus.

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