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Curr Drug Targets. 2003 Oct;4(7):525-36.

Tumor escape from immune response: mechanisms and targets of activity.

Author information

  • 1H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA. dgabril@moffitt.usf.edu

Abstract

Immune system plays an important role in control of tumor progression. Effective antitumor immune response depends on close interaction of several elements of immune system. They include antigen-presenting cells, different subsets of T cells, B cells and NK cells. However, tumor cells developed a number of mechanisms to escape recognition and elimination by immune system. In this review we will discuss these mechanisms and address possible approaches to correct them.

PMID:
14535653
[PubMed - indexed for MEDLINE]
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