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Nat Genet. 2003 Nov;35(3):215-7. Epub 2003 Oct 5.

Dicer is essential for mouse development.

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  • 1Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

Erratum in

  • Nat Genet. 2003 Nov;35(3):287.

Abstract

To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.

PMID:
14528307
[PubMed - indexed for MEDLINE]
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