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    Nat Genet. 2003 Nov;35(3):215-7. Epub 2003 Oct 5.

    Dicer is essential for mouse development.

    Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ.

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    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

    Erratum in

    • Nat Genet. 2003 Nov;35(3):287.

    Abstract

    To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.

    PMID:
    14528307
    [PubMed - indexed for MEDLINE]

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