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Oncogene. 2003 Sep 29;22(42):6639-45.

Pathologic aspects of AIDS malignancies.

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  • 1Department of Human Pathology and Oncology, University of Siena, Siena, Italy.


Since the emergence of the HIV pandemic, a close association between HIV infection and the development of a selected group of cancers has been acknowledged. The introduction of highly active antiretroviral therapy, however, has had a dramatic impact on the incidences of several AIDS-defining malignancies. This suggests the possibility of a direct and indirect role of HIV in HIV-related tumor genesis. The aim of this paper is to review the pathology of AIDS-related malignancies, taking into account the pathogenetic mechanisms and their potential for improving the treatment of these tumors.

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