Your browser version may not work well with NCBI's Web applications. More information here...
1: Integr Physiol Behav Sci. 2003 Apr-Jun;38(2):133-45.Links

Cannabinoid agonists and antagonists modulate lithium-induced conditioned gaping in rats.

Parker LA, Mechoulam R.

Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario. lparker@wlu.ca

Considerable evidence indicates that conditioned gaping in rats reflects nausea in this species that does not vomit. A series of experiments evaluated the potential of psychoactive cannabinoid agonists, delta-9-THC and HU-210, and non-psychoactive cannabinoids, Cannabidiol (CBD) and its dimethylheptyl homolog (CBD-dmh), to interfere with the establishment and the expression of conditioned gaping in rats. All agents attenuated both the establishment and the expression of conditioned gaping. Furthermore, the CB1 antagonist, SR-141716, reversed the suppressive effect of HU-210 on conditioned gaping. Finally, SR-141716 potentiated lithium-induced conditioned gaping, suggesting that the endogenous cannabinoid system plays a role in the control of nausea.

PMID: 14527182 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Lithium (Eskalith CR® , Eskalith® , Lithobid® )

    Lithium is used to treat and prevent episodes of mania (frenzied, abnormally excited mood) in people with bipolar disorder (manic depressive disorder; a disease that causes episodes of depression, episodes of mania, and ...

  • Dronabinol (Marinol® )

    Dronabinol is used to treat nausea and vomiting caused by chemotherapy in people who have already taken other medications to treat this type of nausea and vomiting without good results. Dronabinol is also used to treat l...

  • Source: AHFS Consumer Medication Information