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Phys Rev Lett. 2003 Sep 26;91(13):138701. Epub 2003 Sep 26.

Preferential attachment in the protein network evolution.

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  • 1Compugen Ltd., 72 Pinchas Rosen Street, Tel Aviv 69512, Israel.


The Saccharomyces cerevisiae protein-protein interaction map, as well as many natural and man-made networks, shares the scale-free topology. The preferential attachment model was suggested as a generic network evolution model that yields this universal topology. However, it is not clear that the model assumptions hold for the protein interaction network. Using a cross-genome comparison, we show that (a) the older a protein, the better connected it is, and (b) the number of interactions a protein gains during its evolution is proportional to its connectivity. Therefore, preferential attachment governs the protein network evolution. Evolutionary mechanisms leading to such preference and some implications are discussed.

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