Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Phys Rev Lett. 2003 Sep 26;91(13):138701. Epub 2003 Sep 26.

Preferential attachment in the protein network evolution.

Author information

  • 1Compugen Ltd., 72 Pinchas Rosen Street, Tel Aviv 69512, Israel.

Abstract

The Saccharomyces cerevisiae protein-protein interaction map, as well as many natural and man-made networks, shares the scale-free topology. The preferential attachment model was suggested as a generic network evolution model that yields this universal topology. However, it is not clear that the model assumptions hold for the protein interaction network. Using a cross-genome comparison, we show that (a) the older a protein, the better connected it is, and (b) the number of interactions a protein gains during its evolution is proportional to its connectivity. Therefore, preferential attachment governs the protein network evolution. Evolutionary mechanisms leading to such preference and some implications are discussed.

PMID:
14525344
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for American Physical Society
    Loading ...
    Write to the Help Desk