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Biol Cell. 2003 Sep;95(6):329-33.

Mesial temporal lobe epilepsy: a pathological replay of developmental mechanisms?

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  • 1Cortex et Epilepsie, INSERM EMI 0224, CHUPS, Université Paris VI, 105 boulevard de l'Hôpital, 75013 Paris, France.


Focal epilepsies of the mesial temporal lobe are often associated with a hippocampal sclerosis. Changes in Cl homeostasis and GABAergic signalling in downstream regions, may contribute to the human pathology. A review of changes in cellular and synaptic function and connectivity after de-afferentation suggests this epileptic syndrome may involve a pathological replay of developmental mechanisms.

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