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Genome Biol. 2003;4(10):R69. Epub 2003 Sep 11.

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets.

Author information

  • 1Division of Hematology, Department of Medicine, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.

PMID:
14519204
[PubMed - indexed for MEDLINE]
PMCID:
PMC328458
Free PMC Article

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