Your browser version may not work well with NCBI's Web applications. More information here...
1: Genome Biol. 2003;4(10):R67. Epub 2003 Sep 10.Click here to read Click here to read Links

A high performance test of differential gene expression for oligonucleotide arrays.

Lemon WJ, Liyanarachchi S, You M.

Department of Surgery, 4940 Parkview Place, 10130 Wohl Clinics, Washington University in St Louis, St Louis, MI 63110, USA.

Logit-t employs a logit-transformation for normalization followed by statistical testing at the probe-level. Using four publicly-available datasets, together providing 2,710 known positive incidences of differential expression and 2,913,813 known negative incidences, performance of statistical tests were: Logit-t provided 75% positive-predictive value, compared with 5% for Affymetrix Microarray Suite 5, 6% for dChip perfect match (PM)-only, and 9% for Robust Multi-array Analysis at the p < 0.01 threshold. Logit-t provided 70% sensitivity, Microarray Suite 5 provided 46%, dChip provided 53% and Robust Multi-array Analysis provided 63%.

PMID: 14519202 [PubMed - indexed for MEDLINE]

PMCID: PMC328456