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Genome Biol. 2003;4(10):230. Epub 2003 Sep 24.

Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae.

Author information

  • Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-1340, USA. oaparici@usc.edu

Abstract

Gene inactivation is the cornerstone of functional genetic analysis, but the analysis of essential genes requires conditional inactivation of the gene product. A new study has adapted a simple method for creating conditional alleles to allow large-scale analysis of essential genes in Saccharomyces cerevisiae and has identified a role in DNA replication for a newly identified protein complex.

PMID:
14519191
[PubMed - indexed for MEDLINE]
PMCID:
PMC328445
Free PMC Article

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