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Ann Pharmacother. 2003 Oct;37(10):1502-5.

Aspirin and warfarin versus aspirin monotherapy after myocardial infarction.

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  • 1St. Louis College of Pharmacy, St. Louis, MO, USA.

Abstract

OBJECTIVE:

To review data concerning combined aspirin/warfarin versus aspirin alone for secondary prevention after myocardial infarction (MI).

DATA SOURCES:

Literature was accessed through MEDLINE (1966-September 2002). Search terms included aspirin, warfarin, secondary prevention, and myocardial infarction.

DATA SYNTHESIS:

Despite use of low-dose aspirin after an MI, risk of subsequent death and ischemic events remains high, making strategies for secondary prevention imperative. Relevant, large, long-term studies focusing on dual aspirin/warfarin versus aspirin alone in post-MI patients were evaluated.

CONCLUSIONS:

Aspirin 75-325 mg/d should remain first-line therapy for secondary prevention after MI. Combining aspirin 75-81 mg with warfarin to maintain the international normalized ratio at 2.0-2.5 may provide added benefit, but should be considered only for patients at high risk for thromboembolic events.

PMID:
14519047
[PubMed - indexed for MEDLINE]
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