J Biosci. 2003 Sep;28(5):637-46.

An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants.

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Neurobiotechnology Center, The Ohio State University, Columbus, Ohio 43210, USA. vdubey@mail.ucf.edu

Abstract

Terpenoids are known to have many important biological and physiological functions. Some of them are also known for their pharmaceutical significance. In the late nineties after the discovery of a novel non-mevalonate (non-MVA) pathway, the whole concept of terpenoid biosynthesis has changed. In higher plants, the conventional acetate-mevalonate (Ac-MVA) pathway operates mainly in the cytoplasm and mitochondria and synthesizes sterols, sesquiterpenes and ubiquinones predominantly. The plastidic non-MVA pathway however synthesizes hemi-, mono-, sesqui- and di-terpenes, along with carotenoids and phytol chain of chlorophyll. In this paper, recent developments on terpenoids biosynthesis are reviewed with respect to the non-MVA pathway.

PMID:: 14517367; [PubMed - indexed for MEDLINE]

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An overview of the non-mevalonate pathway for terpenoid biosynthesis in plants.
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J Biosci. 2003 Sep ;28(5):637-46.

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