Format

Send to

Choose Destination
See comment in PubMed Commons below
Acta Biochim Pol. 2003;50(3):743-52.

Azurocidin -- inactive serine proteinase homolog acting as a multifunctional inflammatory mediator.

Author information

  • 1Institute of Biochemistry and Molecular Biology, Wrocław University, Wrocław, Poland. watorek@bf.uni.wroc.pl

Abstract

Azurocidin, also known as cationic antimicrobial protein 37 kDa (CAP37) or heparin-binding protein (HBP) is an inactive homolog of serine proteinases residing in granulocytes. The ability to cleave peptide bond was lost due to replacement of two of the three residues from the conserved catalytic triad characteristic for serine proteinases. Azurocidin has a broad spectrum of antimicrobial activity, mainly against Gram-negative bacteria. It is also recognized as a multifunctional inflammatory mediator for its contracting effects on endothelial cells causing an increase of vascular permeability, capacity to bind endotoxin and ability to attract monocytes to inflammation sites.

PMID:
14515154
DOI:
035003743
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Acta Biochemica Polonica, Inc.
    Loading ...
    Write to the Help Desk