Send to:

Choose Destination
See comment in PubMed Commons below
Opt Lett. 2003 Oct 1;28(19):1739-41.

Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intact.

Author information

  • 1Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843-3120, USA.


Three-dimensional laser-induced photoacoustic tomography, also referred to as optoacoustic tomography, is developed to image animal brain structures noninvasively with the skin and skull intact. This imaging modality combines the advantages of optical contrast and ultrasonic resolution. The distribution of optical absorption in a mouse brain is imaged successfully. The intrinsic optical contrast reveals not only blood vessels but also other detailed brain structures, such as the cerebellum, hippocampus, and ventriculi lateralis. The spatial resolution is primarily diffraction limited by the received photoacoustic waves. Imaged structures of the brain at different depths match the corresponding histological pictures well.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Optical Society of America
    Loading ...
    Write to the Help Desk