Essential role of VLA-4/VCAM-1 pathway in the esta...[J Neuroimmunol. 2003]

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1: J Neuroimmunol. 2003 Sep;142(1-2):17-30. Links

Essential role of VLA-4/VCAM-1 pathway in the establishment of CD8+ T-cell-mediated Trypanosoma cruzi-elicited meningoencephalitis.

Roffê E, Silva AA, Marino AP, dos Santos PV, Lannes-Vieira J.

Laboratório de Autoimunidade e Imuno-regulação, Departamento de Imunologia, Instituto Oswaldo Cruz-Fundação Oswaldo Cruz, Av. Brasil, 4365 Rio de Janeiro, RJ 21045-900, Brazil.

Central nervous system (CNS) damage can occur during Trypanosoma cruzi infection, especially in immunosuppressed patients. The enhanced susceptibility of C3H/He mice to CD8-mediated acute meningoencephalitis is associated with higher up-regulation of vascular cell adhesion molecule-1 (VCAM-1) on CNS vascular endothelia than in the less susceptible C57BL/6. Further, in vitro adhesion of activated peripheral blood cells to CNS blood vessels was abrogated by anti-VLA-4 antibodies that also inhibited cell migration into the CNS of T. cruzi-infected mice. Lastly, the reactivation of meningoencephalitis in immunosuppressed chronically infected mice was associated with VCAM-1 up-regulation. Therefore, we hypothesize that VLA-4/VCAM-1 pathway plays a pivotal role in the establishment of T. cruzi-elicited encephalitis.

PMID: 14512161 [PubMed - indexed for MEDLINE]

Prevalence of CD8(+)alpha beta T cells in Trypanosoma cruzi-elicited myocarditis is associated with acquisition of CD62L(Low)LFA-1(High)VLA-4(High) activation phenotype and expression of IFN-gamma-inducible adhesion and chemoattractant molecules.
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ReviewGeneration, specificity, and function of CD8+ T cells in Trypanosoma cruzi infection.
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ReviewTrypanosoma cruzi-elicited CD8+ T cell-mediated myocarditis: chemokine receptors and adhesion molecules as potential therapeutic targets to control chronic inflammation?
Mem Inst Oswaldo Cruz. 2003 Apr; 98(3):299-304. Epub 2003 Jul 18.

[Mem Inst Oswaldo Cruz. 2003]
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Cited by 1 PubMed Central article

ReviewThe thymus is a common target organ in infectious diseases.
Savino W. PLoS Pathog. 2006 Jun; 2(6):e62.

[PLoS Pathog. 2006]

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Essential role of VLA-4/VCAM-1 pathway in the establishment of CD8+ T-cell-mediated Trypan...Essential role of VLA-4/VCAM-1 pathway in the establishment of CD8+ T-cell-mediated Trypanosoma cruzi-elicited meningoencephalitis.

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Essential role of VLA-4/VCAM-1 pathway in the establishment of CD8+ T-cell-mediated Trypanosoma cruzi-elicited meningoencephalitis.

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