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Nat Rev Mol Cell Biol. 2003 Sep;4(9):690-9.

Nuclear and unclear functions of SUMO.

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  • 1Nuclear Organization and Oncogenesis Unit, INSERM U 579, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France.


Post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells. Sumoylation has crucial roles in the regulatory challenges that face nucleate cells, including the control of nucleocytoplasmic signalling and transport and the faithful replication of a large and complex genome, as well as the regulation of gene expression.

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