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Nat Rev Mol Cell Biol. 2003 Sep;4(9):679-89.

Titin: properties and family relationships.

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  • 1Astbury Centre for Structural Molecular Biology, and School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK.


In striated muscles, the rapid production of macroscopic levels of force and displacement stems directly from highly ordered and hierarchical protein organization, with the sarcomere as the elemental contractile unit. There is now a wealth of evidence indicating that the giant elastic protein titin has important roles in controlling the structure and extensibility of vertebrate muscle sarcomeres.

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