Send to:

Choose Destination
See comment in PubMed Commons below
J Am Chem Soc. 2003 Oct 1;125(39):11804-5.

Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening.

Author information

  • 1Department of Chemistry, New York University, New York, New York 10003, USA.


An improved forward chemical genetics approach was successfully demonstrated using a tagged library concept. A small-molecule triazine library with linkers was used to screen for brain/eye developmental phenotypes in a zebrafish embryo system. This approach enabled the rapid isolation of the target proteins by facile affinity matrix preparation and elucidated the first small-molecule inhibitors for several ribosomal accessory proteins or their complex as the target.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Write to the Help Desk