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Intern Med. 1992 Jul;31(7):917-21.

Klinefelter's syndrome accompanied by diabetes mellitus and diabetes insipidus.

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  • 1Department of Internal Medicine, Ogaki Municipal Hospital, Japan.


The first case of Klinefelter's syndrome accompanied by diabetes insipidus and diabetes mellitus is reported. A 41-year-old man admitted for hyperosmolar diabetic coma with a past history of diabetes insipidus was diagnosed as having Klinefelter's syndrome by endocrinological examination and sex chromosome analysis. In this case, glucose tolerance test was normalized half a year later and blood glucose was well controlled with diet therapy alone.

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