Endocr Relat Cancer. 2003 Sep;10(3):389-96.

Protein kinase C: a target for anticancer drugs?

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Department of Medical Oncology, Cancer Research UK Beatson Laboratories, Alexander Stone Building, Switchback Road, Glasgow G61 1BD, UK.

Abstract

Protein kinase C (PKC) is a family of serine/threonine kinases that is involved in the transduction of signals for cell proliferation and differentiation. The important role of PKC in processes relevant to neoplastic transformation, carcinogenesis and tumour cell invasion renders it a potentially suitable target for anticancer therapy. Furthermore, there is accumulating evidence that selective targeting of PKC may improve the therapeutic efficacy of established neoplastic agents and sensitise cells to ionising radiation. This article reviews the rationale for targeting PKC, focuses on its role in breast cancer and reviews the preclinical and clinical data available for the efficacy of PKC inhibition.

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Endocr Relat Cancer. 2004 Jun;11(2):161-2.

PMID:: 14503915; [PubMed - indexed for MEDLINE]

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