Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2003 Sep 19;301(5640):1731-3.

Demography of dietary restriction and death in Drosophila.

Author information

  • 1Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK.

Abstract

Dietary restriction (DR) increases life-span in organisms from yeast to mammals, presumably by slowing the accumulation of aging-related damage. Here we show that in Drosophila, DR extends life-span entirely by reducing the short-term risk of death. Two days after the application of DR at any age for the first time, previously fully fed flies are no more likely to die than flies of the same age that have been subjected to long-term DR. DR of mammals may also reduce short-term risk of death, and hence DR instigated at any age could generate a full reversal of mortality.

Comment in

PMID:
14500985
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk