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Science. 2003 Sep 19;301(5640):1682-5.

Neuroscience. From molecules to memory in the cerebellum.

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  • 1Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. dlinden@jhmi.edu

Abstract

Neuroscientists have long sought to elucidate the molecular underpinnings of the memories needed to learn, for example, a motor task. In his Perspective, Linden discusses new work (Koekkoek et al.) suggesting that long-term depression in Purkinje cells mediated by protein kinase C signaling is responsible for motor memory in a task called associative eyelid conditioning.

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