Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2003 Nov 7;302(5647):1036-8. Epub 2003 Sep 18.

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.

Author information

  • 1Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. andreas.villunger@uibk.ac.at

Abstract

Apoptosis provoked by DNA damage requires the p53 tumor suppressor, but which of the many p53-regulated genes are required has remained unknown. Two genes induced by this transcription factor, noxa and puma (bbc3), stand out, because they encode BH3-only proteins, proapoptotic members of the Bcl-2 family required to initiate apoptosis. In mice with either noxa or puma disrupted, we observed decreased DNA damage-induced apoptosis in fibroblasts, although only loss of Puma protected lymphocytes from cell death. Puma deficiency also protected cells against diverse p53-independent cytotoxic insults, including cytokine deprivation and exposure to glucocorticoids, the kinase inhibitor staurosporine, or phorbol ester. Hence, Puma and Noxa are critical mediators of the apoptotic responses induced by p53 and other agents.

PMID:
14500851
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for HighWire
    Loading ...
    Write to the Help Desk