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    Nature. 1992 Nov 26;360(6402):313-9.

    Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice.

    Matzuk MM, Finegold MJ, Su JG, Hsueh AJ, Bradley A.

    Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030.

    The inhibins are alpha:beta heterodimeric growth factors that are members of the transforming growth factor-beta family. To understand the physiological roles of the inhibins in mammalian development and reproduction, a targeted deletion of the alpha-inhibin gene was generated by homologous recombination in mouse embryonic stem cells. Mice homozygous for the null allele (inhibin-deficient) initially develop normally but every mouse ultimately develops mixed or incompletely differentiated gonadal stromal tumours either unilaterally or bilaterally. Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity.

    PMID: 1448148 [PubMed - indexed for MEDLINE]

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