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Arthritis Rheum. 1992 Nov;35(11):1387-92.

Premature death with bladder outlet obstruction and hyperprolactinemia in New Zealand black X New Zealand white mice treated with ethinyl estradiol and 17 beta-estradiol.

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  • 1Department of Internal Medicine, University of Missouri-Columbia.

Abstract

OBJECTIVE:

To determine causes of death, estrogen toxicity, and hyperprolactinemia in a murine model of systemic lupus erythematosus (SLE).

METHODS:

Female New Zealand Black x New Zealand White (NZB x NZW) mice were implanted with ethinyl estradiol, 17 beta-estradiol, or empty capsules (controls).

RESULTS:

Estrogen-treated mice developed striking hyperprolactinemia and died prematurely with genitourinary complications.

CONCLUSION:

Implanted estrogens, including 17 beta-estradiol in a dose reported previously to stimulate SLE, contribute to premature death in NZB x NZW mice, through toxic effects. Estrogen therapy increases the level of prolactin, an immunostimulatory hormone.

PMID:
1445459
[PubMed - indexed for MEDLINE]
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