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Trends Pharmacol Sci. 1992 Nov;13(11):413-7.

Development of GPIIb/IIIa antagonists as antithrombotic drugs.

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  • 1Smith-Kline Beecham Pharmaceuticals, King of Prussia, PA 19406.


Thrombosis represents a major target for development of drugs to prevent and treat a variety of cardiovascular and cerebrovascular diseases, which are the leading cause of morbidity and mortality in the Western world. This review by Andy Nichols and colleagues focuses on a central process in thrombosis, namely platelet aggregation, and how it can be inhibited by antagonists of the adhesion molecule GPIIb/IIIa. Successful and future therapeutic applications of GPIIb/IIIa antagonists, and their pharmacology, are considered in detail.

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