Science. 1977 Mar 25;195(4284):1356-8.

Glutamine synthetase: glial localization in brain.

Martinez-Hernandez A, Bell KP, Norenberg MD.

Abstract

Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, gamma-aminobutyric acid, and ammonia metabolism in brain.

PMID:: 14400; [PubMed - indexed for MEDLINE]

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