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Science. 1992 Nov 6;258(5084):964-9.

Selectins: interpreters of cell-specific carbohydrate information during inflammation.

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  • 1Department of Immunology, Genetech, Inc., South San Francisco, CA 94080.


Although a bewildering array of cell surface carbohydrate structures have been described, the physiological relevance of any of these complex molecules has often eluded biologists. A family of cell surface glycoproteins, the "selectins," has a characteristic ability to use some of these carbohydrate structures in adhesive mechanisms that help localize leukocytes to regions of inflammation. This article will review the biology of these carbohydrate-binding adhesive proteins and discuss the potential for developing anti-inflammatory antagonists that could inhibit binding events that are selectin-mediated.

[PubMed - indexed for MEDLINE]
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