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Stereotact Funct Neurosurg. 1992;58(1-4):84-7.

Bilateral fetal grafts for Parkinson's disease: 22 months' results.

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  • 1Department of Neurosurgery, Hua Shan Hospital, Shanghai, ROC.


Five patients with severe Parkinson's disease underwent bilateral multiple graft implants of nondissociated fetal mesodiencephalic tissues. Graft implantation was performed in China following CT-guided stereotactic placement of a novel delivery system. Follow-up has demonstrated substantially reduced levodopa requirements and clinical improvements of motor, postural functions and reduction of freezing and on-off phenomenon. PET utilizing [18F]-dopa, at 14 months in the first case, suggested graft-induced restoration of dopaminergic transmission in the striatum.

[PubMed - indexed for MEDLINE]
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