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Nature. 1992 Oct 29;359(6398):777-8.
A second-generation linkage map of the human genome.
Genethon, Evry, France.
A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to approximately 90% of the estimated length of the human genome.
PMID: 1436057 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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