-
Subregional mapping of 13 single-copy genes on the long arm of chromosome 12 by fluorescence in situ hybridization.
Laboratory of Cancer Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
Subregional localization of 13 single-copy DNA sequences previously assigned to the long arm of chromosome 12 has been performed using the fluorescence in situ hybridization (FISH) technique. The following order is suggested for the 13 mapped genes: cen-->COL2A1-->(VDR-D12S15)-->(D12S17-D12S4++ +-D12S14-D12S6)-->D12S8-->(IAPP-MGF- D12S7-D12S12)-->IGF1-->qter. Eight of the mapped genes clustered at two regions, one at 12q13 (D12S17-D12S4-D12S14-D12S6) and the other at 12q22 (IAPP-MGF-D12S7-D12S12). Our results show that single-copy DNA sequences as small as 500 bp can be successfully mapped by FISH.
PMID: 1427906 [PubMed - indexed for MEDLINE]
-
Cited by 2 PubMed Central articles
-
A candidate metastasis-associated DNA marker for ductal mammary carcinoma.
Achary PM, Zhao H, Fan Z, Gogineni S, Pulijaal VR, Herbst L, Mahadevia PS, Jones JG, Klinger HP, Vikram B.
Breast Cancer Res. 2003; 5(2):R52-8. Epub 2003 Jan 30.
[Breast Cancer Res. 2003]
-
Characterization of the promoter region of the gene for the rat neutral and basic amino acid transporter and chromosomal localization of the human gene.
Yan N, Mosckovitz R, Gerber LD, Mathew S, Murty VV, Tate SS, Udenfriend S.
Proc Natl Acad Sci U S A. 1994 Aug 2; 91(16):7548-52.
[Proc Natl Acad Sci U S A. 1994]