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1: Eur J Clin Microbiol Infect Dis. 1992 May;11(5):427-31.Links

Evaluation of ciprofloxacin and doxycycline in the treatment of Mediterranean spotted fever.

Ruiz Beltrán R, Herrero Herrero JI.

Department of Medicine, University Hospital, Salamanca, Spain.

A comparison was made of the results obtained with ciprofloxacin (750 mg/12 h) and doxycycline (100 mg/12 h), both administered p.o. for one week, in 34 and 36 patients respectively with Mediterranean spotted fever. Apyrexia was achieved after 50.1 +/- 34.2 h (mean +/- SD) of antibiotic therapy in the group of patients treated with ciprofloxacin and in 55.2 +/- 23.3 h in the group treated with doxycycline (no significant statistical differences). Resolution of the remaining signs and symptoms of the disease was achieved faster with ciprofloxacin. Both therapeutic regimens were effective and safe. Although more expensive than doxycycline, ciprofloxacin is a bactericidal compound which is better tolerated and has a lower risk of toxicity and of development of resistance. It can be considered, together with doxycycline, as an antibiotic of first choice in the treatment of Mediterranean spotted fever.

PMID: 1425713 [PubMed - indexed for MEDLINE]

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  • Ciprofloxacin (Cipro® , Cipro® XR, Proquin® XR)

    Ciprofloxacin is used to treat or prevent certain infections caused by bacteria. Ciprofloxacin is also used to treat or prevent anthrax (a serious infection that may be spread on purpose as part of a bioterror attack) in...

  • Doxycycline (Doryx® , Monodox® , Vibramycin® Calcium Syrup, ...)

    Doxycycline is used to treat bacterial infections, including pneumonia and other respiratory tract infections; Lyme disease; acne; infections of skin, genital, and urinary systems; and anthrax (after inhalational exposur...

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