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Clin Endocrinol (Oxf). 1992 Jun;36(6):605-8.

Acromegaly and its treatment in the McCune-Albright syndrome.

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  • 1Department of Medicine, University of Wales College of Medicine, Cardiff, UK.


The McCune-Albright syndrome, comprising polyostotic fibrous dysplasia, cutaneous pigmentation and endocrine hyperfunction, is occasionally complicated by acromegaly due to a pituitary adenoma. We report a patient with the McCune-Albright syndrome and acromegaly, who developed secondary hypothyroidism and hypoadrenalism, in whom surgical removal of the pituitary tumour was technically difficult. A combination of a long-acting somatostatin analogue ('Sandostatin') and external irradiation were therefore used as treatment.

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