Br J Ophthalmol. 1992 Sep;76(9):571-3.

Late onset Leber's optic neuropathy: a case confused with ischaemic optic neuropathy.

Borruat FX, Green WT, Graham EM, Sweeney MG, Morgan-Hughes JA, Sanders MD.

Source

National Hospital for Neurology and Neurosurgery, Neuro-Ophthamology Unit, Queen Square, London.

Abstract

A case is reported of a 63-year-old man with progressive central visual loss in one eye followed 11 months later by involvement of the fellow eye. A diagnosis of chronic ischaemic optic neuropathy was considered. However, despite a negative family history, the absence of electrocardiographic abnormalities, and minimal fundus changes a diagnosis of Leber's optic neuropathy was made on the basis of magnetic resonance imaging findings and the mitochondrial DNA mutation at base pair 11778.

PMID:: 1420066; [PubMed - indexed for MEDLINE]
PMCID:: PMC504353

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Case Reports

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DNA, Mitochondrial

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