Eur J Cancer. 1992;28A(12):1941-5.

4-hydroxyandrostenedione: a new treatment for postmenopausal patients with breast cancer.

Source

Department of Medical Oncology, Charing Cross Hospital, London, U.K.

Abstract

We have evaluated 4-hydroxyandrostenedione, a specific inhibitor of aromatase, as treatment for breast cancer in a phase I dose-ranging study and a phase II study of the best-tolerated dose. 168 postmenopausal patients with locally advanced and metastatic breast cancer were treated intramuscularly. 19% of patients attained a complete or partial response but 26% of those who completed at least 4 weeks treatment responded. Side-effects were least in the group receiving 250 mg every 2 weeks. 13% of patients experienced local discomfort due to the injection and 5% had other side-effects. Serum oestradiol fell to 42.4 and 26.5% of baseline at 7 days after the start of treatment with the 250 mg and 500 mg dose, respectively. We conclude that 4-hydroxyandrostenedione at 250 mg every 2 weeks is a safe and effective form of treatment for postmenopausal patients with metastatic breast cancer.

PMID:: 1419285; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Aromatase inhibition with 4-hydroxyandrostenedione in the treatment of postmenopausal patients with advanced breast cancer: a phase II study. [J Clin Oncol. 1990]
Aromatase inhibition with 4-hydroxyandrostenedione in the treatment of postmenopausal patients with advanced breast cancer: a phase II study.
Höffken K, Jonat W, Possinger K, Kölbel M, Kunz T, Wagner H, Becher R, Callies R, Friederich P, Willmanns W. J Clin Oncol. 1990 May; 8(5):875-80.
Formestane in the treatment of advanced postmenopausal breast cancer. [Ann Oncol. 1994]
Formestane in the treatment of advanced postmenopausal breast cancer.
Possinger K, Jonat W, Höffken K. Ann Oncol. 1994; 5 Suppl 7:S7-10.
4-Hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer. [Lancet. 1984]
4-Hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer.
Coombes RC, Goss P, Dowsett M, Gazet JC, Brodie A. Lancet. 1984 Dec 1; 2(8414):1237-9.
Review Second generation aromatase inhibitor--4-hydroxyandrostenedione. [Breast Cancer Res Treat. 1994]
Review Second generation aromatase inhibitor--4-hydroxyandrostenedione.
Dowsett M, Coombes RC. Breast Cancer Res Treat. 1994; 30(1):81-7.
Review Formestane. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the management of breast cancer and prostatic cancer. [Drugs. 1993]
Review Formestane. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the management of breast cancer and prostatic cancer.
Wiseman LR, McTavish D. Drugs. 1993 Jan; 45(1):66-84.

See reviews... See all...

Cited by 3 PubMed Central articles

Review Recent advances in the treatment of breast cancer. [Postgrad Med J. 1994]
Review Recent advances in the treatment of breast cancer.
Smellie WJ, Sacks NP. Postgrad Med J. 1994 Apr; 70(822):243-6.
Endocrinological and clinical evaluation of two doses of formestane in advanced breast cancer. [Br J Cancer. 1994]
Endocrinological and clinical evaluation of two doses of formestane in advanced breast cancer.
Bajetta E, Zilembo N, Buzzoni R, Noberasco C, Di Leo A, Bartoli C, Merson M, Sacchini V, Moglia D, Celio L. Br J Cancer. 1994 Jul; 70(1):145-50.
Endocrinological and clinical evaluation of exemestane, a new steroidal aromatase inhibitor. [Br J Cancer. 1995]
Endocrinological and clinical evaluation of exemestane, a new steroidal aromatase inhibitor.
Zilembo N, Noberasco C, Bajetta E, Martinetti A, Mariani L, Orefice S, Buzzoni R, Di Bartolomeo M, Di Leo A, Laffranchi A. Br J Cancer. 1995 Oct; 72(4):1007-12.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

4-hydroxyandrostenedione: a new treatment for postmenopausal patients with breas...
4-hydroxyandrostenedione: a new treatment for postmenopausal patients with breast cancer.
Eur J Cancer. 1992 ;28A(12):1941-5.

PubMed
CLINICAL OBSERVATIONS ON RESPIRATORY AND VASOMOTOR DISTURBANCE AS RELATED TO CER...
CLINICAL OBSERVATIONS ON RESPIRATORY AND VASOMOTOR DISTURBANCE AS RELATED TO CERVICAL CORDOTOMIES.
J Neurosurg. 1963 Mar ;20:225-32.

PubMed
Synthesis and concentration of 5-phosphoribosyl-1-pyrophosphate in erythrocytes ...
Synthesis and concentration of 5-phosphoribosyl-1-pyrophosphate in erythrocytes from patients with Down's syndrome.
Ann Rheum Dis. 1977 Jun ;36(3):261-3.

PubMed
Narrowing the gap in health status of minority populations: a community-academic...
Narrowing the gap in health status of minority populations: a community-academic medical center partnership.
Am J Prev Med. 1992 Sep-Oct ;8(5):319-23.

PubMed
Hepatic glycogen synthetase deficiency. Definition of syndrome from metabolic an...
Hepatic glycogen synthetase deficiency. Definition of syndrome from metabolic and enzyme studies on a 9-year-old girl.
Arch Dis Child. 1977 Jul ;52(7):573-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

4-hydroxyandrostenedione: a new treatment for postmenopausal patients with breast cancer.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information