Curr Opin Cell Biol. 1992 Oct;4(5):850-5.

Regulation of cartilage and bone differentiation by bone morphogenetic proteins.

Source

Johns Hopkins University School of Medicine, Baltimore, Maryland.

Abstract

Quantum advances have recently been made in the understanding of the regulation of cartilage and bone differentiation through the identification, purification, genetic cloning and expression of recombinant bone morphogenetic proteins. Bone morphogenetic proteins are a family of pleiotropic differentiation factors with actions on chemotaxis, mitosis, initiation and promotion of chondrogenic and osteogenic phenotypes. They bind extracellular matrix components, heparin and type IV collagen and initiate bone repair. The cascade of cartilage and bone differentiation consists of several continuous phases: initiation, promotion, maintenance and termination.

PMID:: 1419064; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

EBSCO

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Review Initiation and promotion of bone differentiation by bone morphogenetic proteins. [J Bone Miner Res. 1993]
Review Initiation and promotion of bone differentiation by bone morphogenetic proteins.
Reddi AH, Cunningham NS. J Bone Miner Res. 1993 Dec; 8 Suppl 2:S499-502.
Review Bone and cartilage differentiation. [Curr Opin Genet Dev. 1994]
Review Bone and cartilage differentiation.
Reddi AH. Curr Opin Genet Dev. 1994 Oct; 4(5):737-44.
Effects of cartilage-derived morphogenetic proteins and osteogenic protein-1 on osteochondrogenic differentiation of periosteum-derived cells. [Endocrinology. 2001]
Effects of cartilage-derived morphogenetic proteins and osteogenic protein-1 on osteochondrogenic differentiation of periosteum-derived cells.
Gruber R, Mayer C, Bobacz K, Krauth MT, Graninger W, Luyten FP, Erlacher L. Endocrinology. 2001 May; 142(5):2087-94.
Review Cartilage morphogenesis: role of bone and cartilage morphogenetic proteins, homeobox genes and extracellular matrix. [Matrix Biol. 1995]
Review Cartilage morphogenesis: role of bone and cartilage morphogenetic proteins, homeobox genes and extracellular matrix.
Reddi AH. Matrix Biol. 1995 Oct; 14(8):599-606.
Review Bone morphogenetic proteins and skeletal development: the kidney-bone connection. [Pediatr Nephrol. 2000]
Review Bone morphogenetic proteins and skeletal development: the kidney-bone connection.
Reddi AH. Pediatr Nephrol. 2000 Jul; 14(7):598-601.

See reviews... See all...

Cited by 12 PubMed Central articles

Vessel formation is induced prior to the appearance of cartilage in BMP-2-mediated heterotopic ossification. [J Bone Miner Res. 2010]
Vessel formation is induced prior to the appearance of cartilage in BMP-2-mediated heterotopic ossification.
Dilling CF, Wada AM, Lazard ZW, Salisbury EA, Gannon FH, Vadakkan TJ, Gao L, Hirschi K, Dickinson ME, Davis AR, et al. J Bone Miner Res. 2010 May; 25(5):1147-56.
Scaffold stiffness influences cell behavior: opportunities for skeletal tissue engineering. [Open Orthop J. 2008]
Scaffold stiffness influences cell behavior: opportunities for skeletal tissue engineering.
Breuls RG, Jiya TU, Smit TH. Open Orthop J. 2008 May 29; 2:103-9. Epub 2008 May 29.
Endogenous bone morphogenetic proteins mediate 1alpha, 25-dihydroxyvitamin D(3)-induced expression of osteoblast differentiation markers in human dermal fibroblasts. [J Orthop Res. 2009]
Endogenous bone morphogenetic proteins mediate 1alpha, 25-dihydroxyvitamin D(3)-induced expression of osteoblast differentiation markers in human dermal fibroblasts.
Hee CK, Nicoll SB. J Orthop Res. 2009 Feb; 27(2):162-8.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Regulation of cartilage and bone differentiation by bone morphogenetic proteins.
Regulation of cartilage and bone differentiation by bone morphogenetic proteins.
Curr Opin Cell Biol. 1992 Oct ;4(5):850-5.

PubMed
COMPLEX VISUAL CONCEPT IN THE PIGEON.
COMPLEX VISUAL CONCEPT IN THE PIGEON.
Science. 1964 Oct 23 ;146(3643):549-51.

PubMed
Responses of retinal axons in vivo and in vitro to position-encoding molecules i...
Responses of retinal axons in vivo and in vitro to position-encoding molecules in the embryonic superior colliculus.
Neuron. 1992 Nov ;9(5):977-89.

PubMed
Dimensions of outcome with clozapine.
Dimensions of outcome with clozapine.
Br J Psychiatry Suppl. 1992 May ;(17):46-53.

PubMed
PSYCHIATRIC MORBIDITY OF PHYSICIANS.
PSYCHIATRIC MORBIDITY OF PHYSICIANS.
JAMA. 1964 Sep 28 ;189:989-92.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: